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KMID : 0617819910010010129
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Journal of Wonkwang Oriental Medicine
1991 Volume.1 No. 1 p.129 ~ p.151
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Effects of natural and Cultured Ganoderma Incidum in Korea Extract on the Immunocyte Responses in the Mouse
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崔政和/Chio, Jung-Hwa
鄭憲鐸/李起男/Chung, Hun-Taeg/Lee, Ki-Nam
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Abstract
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This study was done to know the effects of Natural Ganoderma or Cultured Ganoderma on the innate immunities, tumor immunities and rosette forming capacities of spleen cells.
The innate immunities were evaluated by measuring the effects of Natural or Cultured Ganoderma on the phagocytic activity and reactive oxygen intermediate(ROI) formation of macrophages.
The effects of Natural or Cultured Ganoderma on the tumor immunities were evaluated by checking the antibody-dependent cellular cytotoxicity(ADCC) and natural killer(NK) cell activities.
The administrations of both Natural and Cultured Ganoderma increased the phagocytic activities and the production of ROI of macrophages from the peritoneal cavities. But the effects caused by Natural Ganoderma were bigger than those by Cultured Ganoderma. Both the Natural and Cultured Ganoderma enhanced the ADCC but did not affect on the NK activity. The capacities of spleen cells to forming rosette were increased greatly bo the administration of Natural Ganoderma and slightly by the administration of Cultured Ganoderma.
The results of this study showed that even though both Natural and Cultured Ganoderma enhanced the innate immunities, tumor immunity, and rosette forming capacity of spleen cells, Natural Ganoderma were better than Cultured Ganoderma in increasing the host´s immune capabilities.
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